Literature search and eligibility criteria Thus, we conducted a systematic review and meta-analysis of RCTs to assess the efficacy and safety of N 2O in patients undergoing puncture biopsy. Recently, several randomized controlled trials (RCTs) investigated the effects of N 2O regarding pain management in patients undergoing puncture biopsy and no consistent conclusion was made. It has the advantages of simple handling, fast onset and few adverse reactions and has been shown to have good analgesic effects in various settings such as dental, emergency treatment, obstetrics and pediatrics.
Nitrous oxide (N 2O) is an inhalational agent with analgesic, sedative and anti-anxiety properties. Puncture biopsy is painful and unpleasant, and the anxiety and fear also increase the perception of pain, which may hinder the patient compliance with future biopsy. It can provide strong proof for identification of benign and malignant tumors and selection of the appropriate remedy scheme. Puncture biopsy is the main way to gain tumor tissue or cell sample for histopathological diagnosis, such as percutaneous liver biopsy (PLB), lumbar puncture (LP), bone marrow puncture and transrectal ultrasound-guided prostate biopsy (TUSPB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This study was supported by clinical medical science and technology innovation project of Jinan (Grant number: 202019018 202019025). Received: JAccepted: Published: June 6, 2023Ĭopyright: © 2023 Wang et al. PLoS ONE 18(6):Įditor: Silvia Fiorelli, Sapienza University of Rome: Universita degli Studi di Roma La Sapienza, ITALY (2023) Efficacy of nitrous oxide in adults undergoing puncture biopsy: A systematic review and meta-analysis of randomized controlled trials. Citation: Wang Z, Wang F, Xing Y, Jiang X, Ding Z, Li Y, et al.
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